PoursinaHakim Digestive Disease Research Center

Articles

2024

A Brief Meta-analysis and Health Risk Assessment of Lead and Cadmium in Meat, Liver, and Kidney of Livestock in Iran

Background: Red meat from livestock is an excellent source of high-quality protein, vitamins, and minerals. This meta-analysis aimed to investigate the levels of two of the most toxic heavy metals; lead (Pb) and cadmium (Cd) in meat and edible offal (liver and kidney) of livestock (sheep, buffalo, and cow) in Iran with assessing their health risk of developing cancer.

The Effectiveness of Psychodynamic Group Therapy on the Components of the Sense of Coherence Among Patients with Colon Cancer

Background: Cancer causes several social and psychological problems and responses, such as denial, anger, and feelings of guilt, which eventually lead to the patient’s psychological coherence collapse. The present study aimed to evaluate the effects of psychodynamic group therapy on the components of the Sense of Coherence (SOC) among patients with colon cancer.

Trend of the polyp and adenoma detection rate by sex and age in asymptomatic average-risk and high-risk individuals undergoing screening colonoscopy, 2012–2019

Background: Adenoma detection rate (ADR) is an imperative quality measure for colorectal cancer (CRC) screening. This retrospective observational study aimed to determine the trend of polyp detection rate (PDR) and ADR in asymptomatic average- and high-risk participants in different age groups who underwent screening colonoscopy over the seven years from April 2012 to March 2019 in a tertiary gastroenterology referral center of Iran.

A pan-cancer analysis indicates long noncoding RNA HAND2-AS1 as a potential prognostic, immunomodulatory and therapeutic biomarker in various cancers including colorectal adenocarcinoma

Background: The HAND2-AS1 (HAND2 Antisense RNA 1) Long noncoding RNA (lncRNA) has emerged as a participant in the initiation of various cancer types, underscoring its pivotal involvement in both oncological processes and immune responses. To gain deeper insights into the functional nuances of HAND2-AS1 and identify novel avenues for cancer immunotherapy, a comprehensive evaluation of this gene was undertaken.

2023

The oncogene Musashi1 encodes novel miRNAs in breast cancer

Background: RNA-binding protein Musashi1 (MSI1) shows an increased expression level in several cancers and has been introduced as a prognostic marker in some malignancies. It is expected that if any miRNA is encoded by this gene, it might have a role in cancer development or could be considered as a prognostic biomarker.

The effectiveness of extradiagnostic group therapy on the severity of symptoms and disease perception of people with irritable bowel syndrome

Background: The aim of this research was to determine the effectiveness of group therapy on the severity of symptoms and perception of the disease in people with irritable bowel syndrome. The research was a semi-experimental type with a one-month follow-up phase. The population consisted of all female patients suffering from irritable bowel syndrome.

Parabens preferentially accumulate in metastatic breast tumors compared to benign breast tumors and the association of breast cancer risk factors with paraben accumulation

Background: Parabens are a category of antimicrobial preservatives that may play a role in the etiology and epidemiology of cancers. Parabens are employed in a wide range of pharmaceuticals, cosmetics, personal care products, andprocessed foods. Parabens are thought to influence the evolution of carcinogenesis in breast cancer by acting as genotoxicants, cell proliferation factors, migratory and metastatic activators, and hyper-accumulate in breast cancer cells.

Lynch-like Syndrome and its Molecular Approaches: A Brief Report and Literature Review

Lung cancer registry and monitoring: Feasibility study and application (fars lung cancer registry project)

Background: Lung cancer (LC) is the second most common and deadliest cancer in the world. Despite the control of the progressive course of LC in developed countries, studies indicate an increase in the incidence of the disease in developing countries. We designed a stepwise approach‑based surveillance system for registering LC in our region (fars lung cancer registry “FaLCaRe” Project).

LncRNA FLVCR1-AS1 functions as competing endogenous RNA (ceRNA) to sponge miR-381-3p and aggravate colorectal cancer via upregulation of Wnt signaling pathway

Background: Colorectal cancer (CRC) is the third most frequent cancer and the second deadliest cancer, worldwide. Long non-coding RNAs (lncRNAs) have been introduced as vital regulators of CRC. lncRNA feline leukemia virus subgroup C receptor 1 antisense RNA 1 (FLVCR1‑AS1) is suggested to play a significant role in the tumorigenesis of several cancers.

Human recombinant soluble PD1 can interference in T cells and Treg cells function in response to MDA-MB-231 cancer cell line

Background: PD1/PDL1 pathway targeting using antibodies shows immune related adverse events in patients with tumors. The masking of PD1 ligand by soluble human PD-1 (shPD-1) probably inhibits the PD1/PDL1 interaction between T cells and tumor cells. Accordingly, the goal of this study was to produce human recombinant PD-1-secreting cells and find out how soluble human PD-1 affects T lymphocyte function.

Evaluation and comparison of therapeutic effects of probiotics and colloidal bismuth subcitrate on abdominal bloating

Background: Functional abdominal bloating is one of the functional gastrointestinal disorders (FGIDs). Here, we aimed to investigate and compare the effects of probiotics and colloidal bismuth subcitrate on abdominal bloating.

Entrepreneurship Development Policies in Iran; A critical Review of the Strategic Document and A Comparison to Alphabet Model of Global Entrepreneurship Monitor

Background: The rapidly changing world, necessitates new demands which forces the governments to change the game in terms of policies to support entrepreneurs to fasten the development of new technologies in response to the needs. The success rates of the policies are monitored and reported by GEM. Iran’s entrepreneurship development indicators have a downward trend in recent years. This study is conducted to analyze the content of Iran's entrepreneurship development policies to uncover the weaknesses for policymaker.

Content Analysis of Entrepreneurship and Employment Development Policies in Iran’s Health Sector: Is It a Health Wealth Promoter?

Background: Growing needs mandates economic growth. Entrepreneurship policies play a significant role in achieving productive employment and sustainable development for the health and wealth of society. This study is conducted to find the accordance of this document with the basic theory of the global alphabet model of entrepreneurship on the one hand and a comparison to the real entrepreneurial and economic achievements as social determinants of health (SDOH) on the other hand.

CRC-ICM: Colorectal Cancer Immune Cell Markers Pattern Dataset

Background: Colorectal cancer (CRC) is the second most common cause of cancer death in the world, and can be identified by the location of the primary tumor in the large intestine: right and left colon, and rectum. Based on the location, CRC shows differences in chromosomal and molecular characteristics, microbiomes, incidence, pathogenesis, and outcome.

Model of Predicting Psychosocial Adaptation to Disease According to Health-Promoting Behaviors with the Mediation Role of Self-Compassion in the Patients with Irritable Bowel Syndrome

Background: The present study was conducted to offer the model of predicting psychosocial adaptation to disease according to health-promoting behaviors with the mediation role of self-compassion in the patients with Irritable Bowel Syndrome (IBS).

A Review of Heavy Metals Accumulation in Red Meat and Meat Products in the Middle East

Background: The problem of food contamination is a matter of concern, which can cause health complications in consumers. Several international organizations have created standard permissible limits for heavy metals in meat products. Livestock such as sheep, cattle, camels, and goats are the most important sources of protein meat in the Middle East (ME) countries.

Comparing the Effects of Psychodynamic Group Psychotherapy and Mindfulness-Based Stress Reduction on Body Image and Emotional Processing in Patients with Colorectal Cancer

Background: Emotional processing plays an important role in dealing with stress related to chronic diseases. The present study aimed to investigate the effects of psychodynamic group psychotherapy (PGP) and mindfulnessbased stress reduction (MBSR) on body image and emotional processing in patients with colorectal cancer.

Comparison of the Effectiveness of Mindfulness Therapy and Interoceptive Exposure on Symptom Severity of Patients with Irritable Bowel Syndrome

Background:Irritable bowel syndrome (IBS) is a debilitating chronic disease due to major changes in the health status and lifestyle of people in recent years; it has been one of the common and significant problems in the field of healthcare and medical professionals, which requires psychological interventions besides the biological treatments due to the accompanying psychological complications. The aim of this study was to compare the effectiveness of mindfulness therapy and interoceptive exposure on symptom severity of patients with IBS.

Novel biomarkers for neoplastic progression from ulcerative colitis to colorectal cancer: a systems biology approach

Background: In recent studies, the void of evaluation and in-depth understanding of unknown clinically relevant potential molecular biomarkers involved in colorectal cancer (CRC) from the inflammatory stage of ulcerative colitis (UC) to CRC metastasis, which can be suitable therapeutic targets, is deeply felt. The regulation and interaction among different cancer-promoting molecules, including messenger RNAs (mRNAs) and micro RNAs (miRNAs) in CRC and its progression, were the aim we pursued in this study.

Perceived stress, anxiety, and depression in women with breast cancer: CIBC study

Background: Women with breast cancer face elevated risk for psychological problems. We aimed to examine to what extent treatment-naïve women with breast cancer are at higher risk for perceived stress and symptoms of anxiety and depression, compared with matched women with benign breast disease and healthy women, and explore the contribution of perceived stress in the association between breast cancer and symptoms of anxiety and depression.

Rescue effect of curcumin against copper toxicity

Background: Turmeric has long been used not only as an indispensable part of Asian cuisine but as a medicinal herb for dressing wounds, bites, burns, treating eye infections and acne. Curcuminoids are the active substances and their synthetic derivatives possess an incredibly wide range of medicinal properties that encompass chelation capacity for multiple heavy metals, antioxidant activity, anti-inflammatory properties, cytotoxicity against cancerous cells, antiviral and antibacterial effects, antihypertensive and insulin sensitizing role, and regulatory role on apoptosis.

The Comparison of the Effectiveness of Trans-diagnostic Treatment and the Acceptance and Commitment Therapy (ACT) on Quality of Life in Patients with Irritable Bowel Syndrome (IBS)

Background: Using new psychological approaches along with biological treatments is an effective measure to reduce secondary mental symptoms caused by biological diseases. The purpose of the present study is to compare the effectiveness of extra diagnostic treatment and treatment based on acceptance and commitment to the quality of life of patients with irritable bowel syndrome.

2022

Antioxidant Effects of Methanol Extract of Dracocephalum kotschyi in Acetic Acid Induced Rat Colitis Model

Background: There is a worldwide trend towards substitute synthetic antioxidants with natural alternatives to treat inflammatory bowel disease (IBD) such as ulcerative colitis (UC). This study was conducted to evaluate the effects of Dracocephalum kotschyi extract on tissue injury and oxidative stress in an acetic-acid induced colitis model.

The Association between Celiac Disease and Eosinophilic Esophagitis among Children, in Isfahan, Iran

Background: The prevalence of eosinophilic esophagitis (EoE) has increased in recent decades. Recent studies have found that the prevalence of EoE in patients with celiac disease (CD) is much higher compared with the general population. In this study, the prevalence of EoE in children with CD was calculated and their clinical symptoms, endoscopic and histopathological findings were compared.

Improved extraction of the extreme thermal regions of breast IR images (book chapter)

Background: Advanced Methods in Biomedical Signal Processing and Analysis presents state-of-the-art methods in biosignal processing, including recurrence quantification analysis, heart rate variability, analysis of the RRI time-series signals, joint time-frequency analyses, wavelet transforms and wavelet packet decomposition, empirical mode decomposition, modeling of biosignals, Gabor Transform, empirical mode decomposition. The book also gives an understanding of feature extraction, feature ranking, and feature selection methods, while also demonstrating how to apply artificial intelligence and machine learning to biosignal techniques.

A Simplified Protocol for Microsatellite Instability Evaluation in Iranian Patients at Risk for Lynch Syndrome

Background: The most important tumor characteristic of Lynch syndrome (LS) is microsatellite instability (MSI). In the current study, BAT34c4 and BAT26 mononucleotide markers were evaluated as part of efforts to test a cost-effective panel for MSI testing in Iranian patients, comparing it with the Promega kit.

The impact of sesamol and exercise on striatal TNF-α level, motor behavior, aversive memory and oxidative stress status in 6-hydroxydopamine lesioned rats

Background: Neuroinflammation and oxidative stress play critical roles in the pathophysiology of Parkinson’s disease (PD), and neuroprotective agents could be helpful to slow down the dopaminergic neurodegeneration. Neuroprotective and antioxidant properties of exercise and sesamol have been previously reported. The current research evaluated the influences of sesamol and exercise on memory and motor impairments, oxidative stress and inflammatory markers in an experimental model of PD.

Phenotypicand Genotypic Characterization of Clinical Isolates of Intracellular Adherent–Invasive Escherichia coli Among Different Stages, Family History, and Treated Colorectal Cancer Patients in Iran

Background: There is increasing evidence showing that microbial dysbiosis impacts the health and cancer risk of the host. An association between adherent–invasive Escherichia coli (AIEC) and colorectal cancer (CRC) has been revealed. Cyclomodulins (CMs) have been receiving increasing attention for carcinogenic changes. In this study, the incidence and features of intracellular AIEC and cyclomodulin-encoding genes were investigated and the phylogenetic grouping and genetic relatedness were evaluated.

Lynch-like Syndrome and its Molecular Approaches: A Brief Report and Literature Review

Background: Lynch syndrome (LS) predisposes individuals to early-onset colorectal and other Lynch-associated cancer. This disorder is an autosomal dominant genetic disturbance caused by germline mutations in one of the mismatch repair genes. Different clinical and molecular criteria are used to diagnose LS. Microsatellite instability testing and immunohistochemistry are two widely used methods for the molecular screening of LS-associated cancers.

Is dairy foods restriction mandatory for inflammatory bowel disease patients: a multinational cross-sectional study

Background: The role of dairy foods in inflammatory bowel disease (IBD) has been controversial and it is debatable if patients with IBD should avoid milk and dairy products or not, as well as the relationship between these foods and symptoms among those population. This multi centric cross-sectional study designed to evaluate if it is really necessary to deprive IBD patients from consumption of dairy foods.

High claudin‑4 antigen expression in triple‐negative breast cancer by the immunohistochemistry method

Background: Triple‑negative breast cancer is a heterogeneous subtype of breast cancer. Claudin is an epithelial tight junctional protein, and also it is a receptor for clostridium perfringens enterotoxin and shows impairment of expression in several cancers. The chief purpose of this study is to assess the claudin‑4 expression in triple‐negative breast cancer (TNBC) Iranian patients and evaluate its correlation with some clinicopathological factors.

Evaluation of the Efficacy and Side Effects of Catheter -Specific Intrauterine Insemination in Infertile Couples, a Randomized Clinical Trial

Background: Intrauterine insemination (IUI) is one of the assisted reproductive techniques, which increases the likelihood of egg being exposed to sperm in the uterus and thus the chances of pregnancy. The purpose of the present study was to compare the efficiency of the Masstec catheter (the internal product) with imported catheter (PMIU) so that, if similar, use domestic production as an alternative to imported.

Evaluation of COVID-19 Pandemic Effects on the Quality of Education from the Perspective of Tabas Nursing School’s Professors in Iran

Background: Dear editor, Coronavirus disease 2019 (COVID-19) is a respiratory disease known as the severe acute respiratory syndrome coronavirus 2 first identified in Wuhan, China. With the spread of the virus, the education system faced a completely unprecedented and great crisis. According to a United Nations Educational, Scientific and Cultural Organization report, more than 87% of students worldwide were affected by the disease, leading to the temporary shutdown of educational institutions.

Constructing Novel ceRNA Networks on MiR-616-3p Reveals LncRNAs as Potential Colorectal Cancer Prognostic Biomarkers

Background: Long noncoding RNAs (lncRNAs) perform as competing endogenous RNAs (ceRNAs) to sponge microRNAs (miRNAs) lead to the advancement of cancer. In this work, we attempted to identify possible long noncoding RNA biomarkers as well as a new regulatory axis in colorectal cancer. This investigation was carried out in consideration of the critical oncogenic function played by miR-616-3p in many malignancies, as well as its regulatory involvement in several signaling pathways.

Nrf2 signaling pathway in trace metal carcinogenesis: A cross-talk between oxidative stress and angiogenesis

Background: A large number of people worldwide are affected by chronic metal exposure, which is known to be associated with different type of malignancies. The mechanisms of metal carcinogenicity are complex in nature, and excessive reactive oxygen species (ROS) generation induced by chronic metal exposure, among the other factors, has been proposed as one of the major mechanisms involved in that process. In tumor cells, ROS buildup may lead to cell death through intrinsic and extrinsic signaling pathways. Furthermore, ROS-mediated redox signaling has a crucial role in angiogenesis, which is recognized as an essential step in tumor progression.

2021

Eugenol Administration Improves Liver Damage Induced by a Fructose‑Rich Diet

Background: The prevalence of metabolic syndrome (MetS) is increasing in developing countries that affects the liver in a variety of ways. This study was designed to investigate the protective role of eugenol on liver damage caused by fructose‑induced MetS.

Rational, design and preliminary results of a cohort study on breast and colorectal cancer to develop a risk assessment model to predict future cardiovascular events. “Cardio vascular events In Breast and Colorectal cancers (CIBC) study

Background: Breast cancer (BC) and colorectal cancer (CRC) are among the most common cancers in Iran. We aimed to develop a risk assessment model to predict the development of cardiovascular events in these patients by performing a 5 year prospective cohort study on a newly diagnosed patients with BC or CRC before they receive any treatment.

The Effect of Combined Training with Dietary Approaches to Stop Hypertension (DASH) on Liver Damage Indices in Patients with Non-Alcoholic Fatty Liver Disease

Background: Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition that is associated with sedentary lifestyle and inappropriate feeding habits. The main purpose of this study was to evaluate the effect of 12 weeks of combined training with dietary approaches to stop hypertension (DASH) diet on alanine transaminase (ALT) enzyme levels, liver fat, and anthropometric indices in patients with NAFLD.

Antioxidant Effects of Methanol Extract of Dracocephalum kotschyi in Acetic Acid Induced Rat Colitis Model

Candida colonization of the esophagus and gastric mucosa; a comparison of patients taking proton pump inhibitors and those taking histamine receptor antagonist drugs

Background: Gastroesophageal candidiasis is a common infection among HIV/AIDS patients and those who are taking PPI and H2RAs drugs. More than 20 Candida spp. can cause different types of mucocutaneous infections in humans. The present study was conducted to assess the antifungal susceptibility testing of clinical Candida spp. isolated from gastroesophageal lesions.

In vitro antifungal susceptibility pattern of Candida species isolated from gastroesophageal candidiasis

WRN Germline Mutation Is the Likely Inherited Etiology of Various Cancer Types in One Iranian Family

Background: Familial cancers comprise a considerable distribution of colorectal cancers (CRCs), of which only about 5% occurs through well-established hereditary syndromes. It has been demonstrated that deleterious variants at the newly identified cancerpredisposing genes could describe the etiology of undefined familial cancers.

Correlation of sPD1 with Procalcitonin and C-Reactive Protein Levels in Patients with Sepsis

Background: Sepsis results from dysregulated host responses to infection, and it is a major cause of mortality in the world. Co-inhibitory molecules, such as PD-1, play a critical role in this process. Considering the lack of information on the relation between sPD1 and sepsis, the present study aimed to examine the sPD1 level in septic patients and evaluate its correlation with procalcitonin (PCT) and C-reactive protein (CRP) levels.

The Comparison of the Effectiveness of Trans-diagnostic Treatment and the Acceptance and Commitment Therapy (ACT) on Emotion Regulation and Illness Perception in Patients with Irritable Bowel Syndrome (IBS)

Background: irritable bowel syndrome is the most common, costly and debilitating type of disorder among functional gastrointestinal disorders. The aim of this study was to compare the effectiveness of transdiagnostic treatment and acceptance and commitment therapy and the control group on emotion regulation and illness perception in patients with irritable bowel syndrome.

A Review on the Phytochemistry, Pharmacology, and Therapeutic Effects of Rheum ribes

Background: Herbal medications are typically used for the treatment of diverse diseases without significant adverse effects. The Rheum ribes (R. ribes), commonly called rhubarb, is a hardy perennial herb and is consumed all over the world. There is growing evidence of the therapeutic benefits of R. ribes.

Modeling structural relationships of with perceived pain life in inflammatory bowel patients (IBD)

Background: Living with the chronic pain of inflammatory bowel disease requires considerable emotional pressure, as pain reduces a person’s emotional abilities so the aim of this study was to explain the Structural model of relationships between family communication patterns and quality of life in patients with inflammatory bowel disease with the pain perception.

Gastrointestinal and kidney manifestations in SARSCoV and SARS-CoV-2 infections: role of angiotensin- converting enzyme 2

Background: The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in 2020, which has a substantial structural similarity to severe acute respiratory syndrome coronavirus (SARS-CoV) that caused the outbreak in 2003, is currently a threat to global health. Lung involvement is the principal clinical feature in infected patients but extra-pulmonary clinical presentations are also common. The reasons for the extensive involvement of other organs are not yet clear.

Calcium and dairy products in the chemoprevention of colorectal adenomas: a systematic review and meta-analysis

Background: The risk of transition to colorectal cancer (CRC) in advanced colorectal adenomas (ACAs) is about 2.5 times higher than the non-advanced ones. This systematic review and meta-analysis was performed to determine the effect of calcium and dairy products on the incidence of CAs and ACAs.

The Circulating Midkine in the Newly Diagnosed Celiac Disease: Clinical Implications

Background: Celiac disease (CeD) is a chronic inflammatory small intestine disorder caused by an abnormal immune response to an array of the epitopes of the wheat gluten and related proteins of rye and barley in genetically susceptible individuals. Midkine (MK) is an angiogenic cytokine, chemotactic in the direction of polymorphonuclear neutrophils and macrophages, and a T‑regulatory cell suppressor. So far, a possible relationship with CeD has not yet been explored. Diagnosis of CeD is based on serologic test in a clinical setting suggestive of CeD and confirmatory histologic examination of the duodenal biopsy. The objective of this study was to measure and compare the circulating MK in the celiac patients and healthy individuals.

2020

Gastrointestinal and renal complications in SARS-CoV-2-infected patients: Role of immune system

Background: The recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease has been accompanied by various gastrointestinal (GI) and renal manifestations in significant portion of infected patients. Beside studies on the respiratory complications of coronavirus infection, understanding the essential immunological processes underlying the different clinical manifestations of virus infection is crucial for the identification and development of effective therapies.

Flaxseed oil supplementation on severity of depression and brain-derived neurotrophic factor: a randomized, double blind placebo controlled clinical trial

Background: Emerging clinical studies suggest that flaxseed oil may be an effective intervention for the management of depression. The current trial was conducted to assess the effect of flaxseed oil supplementation on the Brainderived neurotrophic factor (BDNF), and the psychological status of women with depression.

TiO2 nanotubes/reduced GO nanoparticles for sensitive detection of breast cancer cells and photothermal performance

Background: In this study, we developed a simple and cost effective aptasensor based on TiO2 nanotubes–reduced graphene oxide (TiO2 nanotube-rGO) linked to MUC1 aptamers for ultrasensitive electrochemical detection of breast cancer cell (MCF-7). Moreover, the photothermal performance of nanohybrid TiO2-rGO was investigated for cancer treatment. In this regard, after synthesize of TiO2 nanotubes via anodization process, TiO2 nanotubes–rGO hybrid was synthesized by UV assisted reduction of GO and subsequent TiO2 nanotubes attachment to rGO sheets.

Prevalence of Mismatch Repair-Deficient Colorectal Adenoma/Polyp in Early-Onset, Advanced Cases: a Cross-Sectional Study Based on Iranian Hereditary Colorectal Cancer Registry

Background: Lynch syndrome (LS) increases the risk of many types of cancer, mainly colorectal cancer (CRC). The purpose of this study was to assess the prevalence of mismatch repair (MMR) deficiency in patients under the age of 50 with advanced adenomatous polyps, aiming at an early diagnosis of LS.

Prolactin receptor expression as a novel prognostic biomarker for triple negative breast cancer patients

Background: Prolactin receptor (PRLR) is a novel emerging prognostic biomarker in different cancers, especially in breast cancer. However, there is limited information about the association of PRLR expression and triple-negative breast cancers (TNBC) prognosis.

A histopathological image dataset for grading breast invasive ductal carcinomas

Background: Breast cancer is a common cancer in women, and one of the major causes of death among women around the world. Invasive ductal carcinoma (IDC) is the most widespread type of breast cancer with about 80% of all diagnosed cases. Early accurate diagnosis plays an important role in choosing the right treatment plan and improving survival rate among the patients. In recent years, efforts have been made to predict and detect all types of cancers by employing artificial intelligence.

Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer

Background: Our knowledge about correlation of androgen receptor expression and clinicopathological properties of triple-negative breast cancer (TNBC) patients is inadequate, particularly in the Iranian population. The main aim of the present study was to assess the AR expression in TNBC Iranian patients and evaluate its correlation with their clinicopathological parameters.

2019

Paraben Content in Adjacent Normal-malignant Breast Tissues from Women with Breast Cancer

Background: Accumulation of estrogenic compounds and other carcinogens in normal breast tissues contributes to unpredictable breast cancer incidence during adolescence and throughout life. To assess the role of parabens in this phenomenon, the paraben content of adjacent normal-malignant breast tissues is measured in women with breast cancer living in Isfahan Province, Iran.

The Effect of Nursing Consultation on Knowledge and Practice of Patients with Celiac for Adherence to Gluten-Free Diet

Background: Non-compliance to gluten-free diet (GFD), due to less of knowledge and inappropriate nutritional behaviors, is associated with an increase in disease progression and long-term complications in patients with celiac. The aim of this study was to determine the effect of nursing consultation on knowledge and practice of patients with celiac for adherence to GFD.

Predictive value of colonic transit time indices for differentiating nonnormal from normal sensation in children with chronic functional constipation identified by anorectal manometry

Background: Constipation is a common disorder in pediatrics, although the underlying pathogenesis is not fully understood. The current study aimed at evaluating the efficacy of different colonic transit time (CTT) indices for differentiating normal from nonnormal sensation in children with chronic functional constipation identified by anorectal manometry (ARM).

Relations between Coping Skills, Symptom Severity, Psychological Symptoms, and Quality of Life in Patients with Irritable Bowel Syndrome

Background: Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders with significant impact on quality of life (QOL). Considering the role of stress in the clinical course of IBS, we investigated associations between stress coping skills and symptoms and QOL in IBS patient.

Protective effects of walnut extract against oxidative damage in acetic acid-induced experimental colitis rats

Background: Walnuts (Juglans regia), has been shown to exert anti-inflammatory and antioxidant effects. The present study was designed to evaluate the antiinflammatory and antioxidant effects of walnut extract (WE) on an experimental model of ulcerative colitis caused by intracolonic administration of acetic acid in rats.

Over-expression of low-density lipoprotein receptor-related Protein-1 is associated with poor prognosis and invasion in pancreatic ductal adenocarcinoma

Background: Low-density lipoprotein receptor-Related Protein-1 (LRP-1) has been reported to involve in tumor development. However, its role in pancreatic cancer has not been elucidated. The present study was designed to evaluate the expression of LRP-1 in Pancreatic.

Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients

Background: Increased number of intestinal intraepithelial lymphocytes (IELs) is a key histological finding in the diagnosis of celiac disease (CD); however, the number of IELs in celiac patients and healthy subjects may vary from one region to another. Additionally, there are some seronegative celiac patients with a borderline histology.

Effects of Ramadan Fasting on the Symptoms of Gastroesophageal Reflux Disease

Background: The effects of Ramadan fasting on gastroesophageal reflux disease (GERD) remains unknown, and few studies have been conducted in this regard. The nutritional, physiological, psychological, and behavioral changes in fasting individuals during Ramadan may affect the status of GERD. The present study aimed to evaluate the effects of these changes on the symptoms of GERD using a meticulous method.

The insulin‐like growth factor binding protein‐3 and its death receptor in pancreatic ductal adenocarcinoma poor prognosis

Background: Insulin‐like growth factor binding protein‐3 (IGFBP‐3) and its newly discovered death receptor (IGFBP‐3R) have been reported to involve in a wide variety of cancers. However, their role in pancreatic ductal adenocarcinoma (PDAC) has not been elucidated yet. Here, 478 pancreatic cancers were screened for primary PDAC tumors.

Comparing the Effect of Aripiprazole with Nortriptyline on Severity of Irritable Bowel Syndrome

Background: Neuropsychiatric factors play important roles in symptoms of irritable bowel syndrome (IBS). Mood disorders such as bipolar disorder are prevalent among patients with IBS. Antidepressants are used traditionally for management of IBS symptoms but antibipolar agents have not been studied. Aripiprazole, an antibipolar agent, was selected because of having the least anticholinergic side effects.

Sleep quality and associated factors in Iranian inflammatory bowel disease patients

Background: Sleep is essential in maintaining health and quality of life. Inflammatory bowel disease (IBD) patients suffer from poor sleep quality. This study aimed to investigate the prevalence of sleep disturbances in Iranian IBD patients as well as the variables which can be attributed to the quality of sleep in IBD patients.

Inflammatory Bowel Disease Registry and Monitoring: Feasibility Study and Application (Isfahan Inflammatory Bowel Disease Surveillance Project)

Background: Inflammatory bowel disease (IBD) incidence has been increased in Iran as a developing country. Surveillance is a standard method for accessing valid data about disease epidemiology to make relevant decisions for disease control, prevention, and management. We designed Isfahan IBD Surveillance Project (IISP) to make a surveillance system in this area.

Simvastatin in Treatment of Non-alcoholic Steatohepatitis: A Clinical Trial

Background: Statins may lower the liver enzymes in steatohepatitis not only by anti-hyperlipidemic but also with tissue anti-inflammatory effects. This study evaluated safety and efficacy of Simvastatin in treatment of patients with NASH.

2018

Establishment and development of the first biobank of inflammatory bowel disease, suspected to primary immunodeficiency diseases in Iran

background: Inflammatory bowel disease (IBD) might be an immunodeficiency rather than an excessive inflammatory reaction. IBD, suspected to primary immunodeficiency diseases biobank (IBDSPIDB) as a resource for researches can help improve the prevention, diagnosis, and illness treatment and the health promotion throughout the society. Therefore, we launched the biobank of IBDSPID for the first time in Iran.

Assessment of anemia in patients with various types of inflammatory bowel disease under medical therapy

Background: Anemia is a usual systemic complication of inflammatory bowel disease (IBD) and can be presented in combination of iron deficiency anemia (IDA) and anemia of chronic disease (ACD). In the present study, anemia in IBD was assessed.

Combination of diclofenac and aggressive hydration for the prevention of post-ERCP pancreatitis

Background: The aim of this study is To investigate whether aggressive hydration can increase the efficacy of prophylactic non-steroid anti-inflammatory drugs (NSAIDs) in prevention of post-ERCP pancreatitis. NSAIDs are recommended for the prevention of PEP; however, whether aggressive hydration can have additional benefits in this regard is not known.

Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer

Background: Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which short tandem repeats are prone to mutations along with DNA sequences. It is due to DNA‑mismatch‑repair system deficiency because of a germline/somatic mutation in mismatch‑repair (MMR) genes. The germline mutations lead to Lynch syndrome (LS) while epigenetic gene silencing results in sporadic CRC tumors.

Transcultural Adaptation and Validation of Persian Version of Celiac Disease Questionnaire (CDQ); A Specific Questionnaire to Measure Quality of Life of Iranian Patients

Background: The assessment of health-related quality of life has become an important primary or secondary outcome measure in clinical and epidemiologic studies. The aim of this study was to validate a Persian version of Celiac Disease Questionnaire (CDQ) for Celiac disease (CD) among Iranian patients.

Promising effect of rapamycin on multiple sclerosis

Background: The routine therapies for relapsing-remitting multiple sclerosis (RRMS) are common disease-modifying medications, yet are not effective in all patients. The aim of the present clinical trial was to evaluate the therapeutic effects of rapamycin on the clinical and radiological aspects, regulatory T cells proliferation and FOXP3 and GARP gene expression in the patients with RRMS.

2017

Quality of life in inflammatory bowel disease patients: A cross‑sectional study

Background: Inflammatory bowel disease (IBD) has a significant impact on health‑related quality of life (HRQOL). This study aims to investigate the variables which can be attributed to HRQOL in IBD patients.

Familial Colorectal Cancer Type X in Central Iran: A New Clinic pathologic Description

Background: Familial colorectal cancer type X (FCCX) is a subtype of mismatchrepair (MMR)-proficient colorectal cancerin whichthe patients are clinicallyat risk for Lynch syndrome (LS), a common hereditary cancer predisposing syndrome.In this study, we describeda new clinicopathological feature of the condition in central Iran.

Diagnostic value of alarm symptoms for upper GI malignancy in patients referred to GI clinic: A 7 years cross sectional study

Background: Early upper gastrointestinal (UGI) cancer detection had led to organ‑preserving endoscopic therapy. Endoscopy is a suitable method of early diagnosis of UGI malignancies. In Iran, exclusion of malignancy is the most important indication for endoscopy.

Simplified microsatellite instability detection protocol provides equivalent sensitivity to robust detection strategies in Lynch syndrome patients

Background: Germline mutations in mismatch repair (MMR) genes cause Lynch syndrome (LS). LS is an inherited disease, and an important consequence of MMR deficiency is microsatellite instability (MSI) phenotype. MSI phenotype influences the efficacy of 5 fluorouracil (5-FU) chemotherapy.

Effects of Ramadan Fasting on Dyspepsia Symptoms

Background: A few studies have shown that during Ramadan, gastrin, pepsin, and acid secretion are increased and some changes in nutrition of fasting people may deteriorate dyspepsia symptoms. On the other hand stopping smoking and alcohol use and probable psychosocial factors may improve dyspepsia symptoms.

Effectiveness of Quercus brantii hydro alcoholic extract on dyspepsia: A randomized, double blind clinical trial

Background: We aimed to evaluate the effectiveness of hydroalcoholic extract of Quercus brantii’s nut on clinical, endoscopic, and pathological fi ndings of patients with dyspepsia.

Effect of Ramadan Fasting on Alanine Aminotransferase (ALT) in Non- Alcoholic Fatty Liver Disease (NAFLD)

Background: effect of Ramadan fasting on non-alcoholic fatty liver disease (NAFLD) is unknown, and limited studies have been conducted in this regard. Nutritional and behavioral changes in fasting individuals during Ramadan may affect NAFLD, including a high- fat and high- calorie diet, alterations of the body weight and sleep patterns, and insufficient physical activity. The present study aimed to evaluate the effects of these changes on alalie aminotransferase (ALT), an important indicator of NAFLD deterioration.

Comparison of Sub acromial Ketorolac Injection versus Corticosteroid Injection in the Treatment of Shoulder Impingement Syndrome

Background: Subacromial impingement syndrome is the most common cause of shoulder pain and restriction in range of motion in the world. The aim of this study was to compare the efficacy of subacromial injection of ketorolac with the injection of corticosteroid for the treatment of subacromial impingement syndrome.

Predicting Factors for the Communication between hydatid Cyst and Biliary Tract

Background: Hydatid cyst communicated with biliary tract increases the morbidity and mortality rates. Therefore, early detection and treatment are vital.

2016

MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Detection of Microsatellite Instability in Iranian Patients with Hereditary Nonpolyposis Colorectal Cancer (HNPCC).

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary or sporadic, demonstrate better prognosis, altered response to fluorouracil (5FU) chemotherapy and altered operative approach. It is now recommended to perform MSI testing for all new cases of colorectal cancers regardless of being categorized as hereditary or sporadic. This study aimed to evaluate MT1XT20 mononucleotide marker in Iranian patients with hereditary nonpolyposis colorectal cancer (HNPCC). The samples were further characterized using Promega five-marker MSI testing panel and immunohistochemical (IHC) technique.

Simultaneous Helicobacter Pylori Infection in Gastric Mucosa and Gallbladder Mucosa in Patients with Cholecystitis; Is There Any Relationship?

Background: This study aimed to assess the prevalence of Helicobacter pylori infection in gastric and gallbladder in patients with acute cholecystitis or symptomatic cholelitiasis undergoing cholecystectomy.

Sleep Quality and its Associated Factors in Iranian Patients with Breast Cancer

Background: Sleep disturbances are common, but widely underdiagnosed in cancer patients. Thus, the aim of the present study was to evaluate sleep quality and its associated factors among women with breast cancer.

Tension-free Primary Closure, Secondary Intention, and Limberg Flap, Which Is More Effective in Treatment of Uncomplicated Pilonidal Sinus Disease?

Background: This study was performed to compare the efficacy and long-term outcomes of three surgical treatments for uncomplicated pilonidal sinus disease, tension-free primary closure, Limberg flap, and secondary intention (wide excision and packing).

Three-Month and Three-Year Survival Rates and Complications of Transthoracic Surgery in Patients with Esophageal Cancer Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences

Background: Nowadays, esophageal cancer is among the most malignant cancers with high mortality and morbidity. Although reasonable progress in radiotherapy and chemotherapy has been made, still esophagectomy is the main treatment for the disease. Using esophagectomy induces a durable palliation and provides possible cure. This study aimed to assess the three-month and three-year survival rates and complications of transthoracic surgery in patients with esophageal cancer.

Linguistic validation of the Sleep Disturbance Scale for Children (SDSC) in Iranian children with Persian language

Background: The aim of this study was linguistic validation of the Sleep Disturbance Scale for Children (SDSC) in Iranian children with Persian language.

Relationship between articular and nonarticular manifestations in inflammatory bowel Diseases

Background: Musculoskeletal manifestations (MSM) of inflammatory bowel diseases (IBDs) are usually the most frequent extraintestinal manifestations. However, they are not paid enough attention during regular office visits. This cross‑sectional study aimed to draw a clinical picture of MSM and their relationships with other findings in patients with IBD.

Setting up the First Registry for Inflammatory Bowel Disease, Suspected to Primary Immunodeficiency Diseases in Iran

Background: inflammatory bowel disease (IBD) has been considered a hyperinflammatory state due to disturbed interactions between the immune system and the commensal bacterial flora of the gut and suggesting IBD asa primary immunodeficiencies (PID). Therefore a registry launched about IBD, suspected to PID (IBDSPID) for the first time in Iran to raise awareness about this disease, to identify its risk factors, to early diagnosis and treatment.

Effects of Physical Activity on Risk of Colorectal Cancer: A Case–control Study

Background: The prevalence of colorectal cancer (CRC) is rapidly increasing in Iran. It holds the most prevalent cancer after skin, breast, and gastric cancers among the Iranian population. The current study was designed to investigate the effects of leisure time, occupational and household physical activity as well as exercise on the risk of CRC in the Iranian population.

Evaluation of MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Characterizing Microsatellite Instability in Persian Lynch Syndrome Patients

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy. It is now recommended to perform MSI testing for all new cases of colorectal cancer regardless of being categorized as hereditary or sporadic.

Sleep quality in women with systemic lupus erythematosus:contributing factors and effects on health-related quality of life

Background: Sleep quality disturbances are common in patients with systemic lupus erythematosus (SLE). We evaluated sleep quality and its contributors in women with SLE. Also we evaluated the effects of sleep quality disturbance on patients’ health-related quality of life (HRQoL).

Effects of Intraperitoneal dministration of Simvastatin in Prevention of Postoperative Intra-abdominal Adhesion Formation in Animal Model of Rat

Background: To determine the preventive effects of local administration of simvastatin for postoperative intraabdominal adhesion formation in animal model of rat.

2015

Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

Background: Microsatellite instability (MSI) is a mutational signature that is the hallmark of Lynch syndrome, and MSI testing is a cost-effective method to screen the disease. Since there is no enough data about MSI status and associated clinicopathologic features of hereditary nonpolyposis colorectal cancer (HNPCC) in Iran, our study is a new trial to describe them in center of Iran (Isfahan)

Tumor microsatellite instability and clinicopathologic features in Iranian colorectal cancer patients at risk for Lynch syndrome

Linguistic Validation of the M. D. Anderson Symptom Inventory in Persian-Speaking Iranian Cancer Patients

Background: Various symptoms frequently affect cancer patients’ quality of life. Appropriate assessment of these symptom provides valuable data for cancer managemen.

Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients

Background: Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients.

Immunohistochemical analysis of mismatch repair proteins in Iranian colorectal cancer patients at risk for lynch syndrome

Background: Hereditary non-polyposis colorectal cancer (HNPCC) is a common hereditary cancer predisposing syndrome has molecular and clinicopathological features still have remained ambiguous within Iranian populations. We discuss in this article some molecular and clinicopathological features of the condition.

Molecular Analysis of Iranian Colorectal Cancer Patients at Risk for Lynch Syndrome: a New Molecular,Clinicopathological Feature

Background: Microsatellite instability (MSI) and mismatch repair (MMR) gene expression present a hallmark mutational signature of Lynch syndrome as a common hereditary cancer predisposing condition. Since there is not enough data of molecular and clinicopathological aspects of the disease in Iranian populations, this article is a new description in Central Iran.

Health related quality of life in irritable bowel syndrome patients, Kashan, Iran: A case control study

Background: Irritable bowel syndrome has significant impacts on the quality of life (QOL) but IBS subtypes may be different in QOL. This study aimed to assess QOL in IBS subtypes and also two prevalent questionnaires applied to evaluate the QOL in IBS.

Synbiotic containing Bacillus coagulans and fructo-oligosaccharides for functional abdominal pain in children

Background: We evaluated the effectiveness of a synbiotic in the treatment of childhood functional abdominal pain (FAP). Probiotics are effective in the treatment of functional gastrointestinal disorders in adult patients, but there is lack of information in children.

Evaluation of The Mean Percentages of The Peripheral Blood Gamma Delta T Lymphocytes in The Healthy Subjects and Celiac Patients in Isfahan

Background: An elevation in the mean percentages of the gamma delta T lymphocytes per total T cells in the epithelium of the small intestine has a diagnostic value for celiac disease. This study aimed to measure the percentages of the peripheral blood gamma delta T lymphocytes in the adults' celiac disease and healthy controls.

Phenotypical characterization of the peripheral blood T cells in patients with celiac disease: does it differentiate suspicious celiac disease cases?

Background: The present study aimed to study the immunological changes seen in the intestinal epithelium of the celiac patients could also be detected in the peripheral blood lymphocyte populations. Celiac disease (CD) is a small bowel enteropathy caused by permanent wheat gluten intolerance. One of the earliest signs of CD is an increase in the numbers of the intestinal intraepithelial lymphocytes (iIEL).

Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases

Background: Evidence exists on the association between vitamin D deficiency and inflammatory bowel diseases (IBD). Aims To investigate whether vitamin D level is associated with disease activity and quality of life in IBD patients.

2014

Evaluating the Validity and Reliability of Persian Version of The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire for Colorectal Cancer (EORTC QLQ-CR29)

Background: The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire for Colorectal Cancer (EORTC QLQ-CR29) is developed to specifically evaluate the quality of life in patients with colorectal cancer. In this study, we aimed to validate the QLQ-CR29 in Iranian patients with Persian language linguistically and to determine its psychometric properties.

Citalopram for pediatric functional abdominal pain: a randomized, placebo-controlled trial

Background: Antidepressants are effective in adults with pain-related functional gastrointestinal disorders. We investigated the effectiveness of citalopram in the treatment of childhood functional abdominal pain (FAP).

Mebeverine for Pediatric Functional Abdominal Pain: A Randomized, Placebo-Controlled Trial

Background: Few studies are conducted on the efficacy of antispasmodics in the treatment of functional gastrointestinal disorders in children. We evaluated the effectiveness of a smooth-muscle relaxant (mebeverine) in the treatment of childhood functional abdominal pain (FAP).

Premedication with sublingual or oral alprazolam in adults undergoing diagnostic upper gastrointestinal endoscopy

Background: Diagnostic esophagogastroduodenoscopy (EGD) is uncomfortable for most patients. We determined the efficacy of alprazolam, administered orally or sublingually, as premedication for sedation during EGD.

The involvement of the HLA-DQB1 alleles in the risk and the severity of Iranian coeliac disease patients

Background: Coeliac disease (CD) is a highly prevalent autoimmune disorder that is triggered by the ingestion of wheat gluten and related proteins in genetically susceptible individuals. The CD is associated with human leucocyte antigen (HLA) genes particularly with HLA-DQ alleles encoding HLA-DQ2 and DQ8 proteins.

sleep and psychological disorders in patients with inflammatory bowel diseases; another potential role of vitamin D deficiency

Pulmonary function tests in ulcerative colitis

Background: Pulmonary impairment in patients suffering ulcerative colitis (UC) has been suggested by several investigators using standard pulmonary function tests (PFTs). This changes in pulmonary function associated with minimal respiratory symptoms have been documented, especially in patients with active disease. The aim of this prospective study was to determine airway resistance and lung volumes in patients with UC who have no respiratory symptoms in comparisons to a healthy control group.

Evaluating the Validity and Reliability of Persian Version of Lupus Quality of Life (LupusQol) Questionnaire in Iranian Patients

Background: Quality of life is of the most important outcomes measured in patients with systemic lupus erythematosus (SLE). The Lupus Quality of Life (LupusQoL) questionnaire is designed to specifically assess quality of life in these patients. This study aimed to evaluate validity and reliability of the Persian version of this questionnaire in Iranian patients.

Linguistic Validation of the LupusQoL for the Assessment of Quality of Life in Iranian Patients with Systemic Lupus Erythematosus

Background: We evaluated the psychometric properties of the Persian LupusQoL for the evaluation of quality of life in Iranian systemiclupus erythematosus (SLE) patients.

Magnetic resonance cholangiography compared with endoscopic retrograde cholangiography in the diagnosis of primary sclerosing cholangitis

Background: Magnetic resonance cholangiography (MRC) has gained popularity for diagnosing primary sclerosing cholangitis (PSC). We determined the accuracy of MRC compared with endoscopic retrograde cholangiography (ERC) for diagnosing PSC.

P wave duration and dispersion in Holter electrocardiography of patients with obstructive sleep apnea

Background: The underlying mechanisms of the association between obstructive sleep apnea (OSA) and atrial fibrillation (AF) remained unclear. We investigated P wave parameters as indicators of atrial conduction status among OSA patients.

Seropositivity of cytomegalovirus in patients with recurrent pregnancy loss

Background: Some evidence has shown a relationship between human cytomegalovirus (CMV) infection and pregnancy loss. However, whether recurrent or latent CMV infection or altered immune response to CMV is related to recurrent pregnancy loss (RPL) is unclear. We evaluated CMV infection and avidity of antibodies to CMV in women with RPL.

Sleep disorders in systemic lupus erythematosus. Does vitamin D play a role?

Background: Sleep disorders are common among patients with systemic lupus erythematosus (SLE) with unclear underlying mechanisms. We assessed the role of vitamin D in sleep quality of patients with SLE.

2013

The status of lead and cadmium in soils of high prevalenct gastrointestinal cancer region of Isfahan

Background: Cadmium and lead compounds are classified as human carcinogens by several regulatory agencies. Twenty five percent of all cancer‑related deaths are attributed to gastrointestinal cancers (GI Ca). We investigated the levels of 2 different heavy metals (Cd and Pb) in the soils of the Lenjanat region, Isfahan province, Central Iran where intensive agriculture is surrounded by different industries like steel and cement‑making factories and mining and gastrointestinal cancers are very common in this province.

Comparison of Lactobacillus Sporogenes plus mineral oil and mineral oil alone in the treatment of childhood functional constipation

Background: Functional constipation is one of the most prevalent childhood gastrointestinal disorders. We evaluated effects of adding a probiotic to mineral oil in the treatment of functional constipation in children.

The Psychometric Properties of the Persian Migraine-Specific Quality of Life Questionnaire Version 2.1 in Episodic and Chronic Migraines

Background: Migraine-specific quality of life (MSQ) is a valid and reliable questionnaire. Linguistic validation of Persian MSQ questionnaire, analysis of psychometric properties between chronic and episodic migraine patients, and capability of MSQ to differentiate between chronic and episodic migraines were the aims of this study.

2012

Two novel mutations in hMLH1 gene in Iranian hereditary non-polyposis colorectal cancer patients

Background: Abstract Hereditary non-polyposis colorectal cancer (HNPCC) is one of the most common forms of hereditary colorectal cancer. It is an autosomal dominant disorder resulting from germline mutations in DNA mismatch repair genes.

Effect of rs6983267 polymorphism in the 8q24 region and rs4444903 polymorphism in EGF gene on the risk of sporadic colorectal cancer in Iranian population

Background: Colorectal cancer (CRC) is among the major causes of cancer-related morbidity, mortality, and human health problem worldwide. Single-nucleotide polymorphisms (SNPs) in different genes are reported to be effective in increased risk of CRC in different ethnicpopulation.

Hereditary nonpolyposis colorectal cancer and familial colorectal cancer in Central part of Iran, Isfahan

Background: There is a lack of data on familial aggregation of colorectal cancer (CRC) in Iran. We aimed to determine the frequency of hereditary nonpolyposis colorectal cancer (HNPCC) and familial colorectal cancer (FCC) and to determine the frequency of extracolonic cancers in these families in Isfahan.

Irritable Bowel Syndrome–like Symptoms in Patients with Inflammatory Bowel Disease in Clinical Remission Phase are Related to Gut Inflammation

Background: Symptoms consistent with irritable bowel syndrome (IBS) are common among IBD patients in remission phase, and clinicians have difficulties in interpreting such symptoms as an ongoing disease activity or a coexistent IBS. We investigated if the assessment of Fecal Calprotectin (FC) could be helpful in this regard

Frequency of Celiac Disease in Adult Patients with Typical or Atypical Malabsorption Symptoms in Isfahan, Iran

Background: Atypical presentations of celiac disease (CD) have now been shown to be much more common than classical (typical) form. We evaluated the frequency of CD among adult patients with typical or atypical symptoms of CD.

Serologic celiac disease in patients with inflammatory bowel disease

Background: There is an association of celiac disease (CD) with several gastrointestinal illnesses. We aimed to determine the prevalence of CD in patients with inflammatory bowel disease (IBD) to evaluate the value of the routine serological tests for CD in these patients.

Should We Look for Celiac Disease among all Patients with Liver Function Test Abnormalities?

Background: Celiac disease (CD) has been found in up to 10% of the patients presenting with unexplained abnormal liver function tests (LFT). As there is no precise data from our country in this regard, we investigated the prevalence of CD in patients presenting with abnormal LFT.

Restless legs syndrome in patients on maintenance hemodialysis and peritoneal dialysis

Background: Restless legs syndrome (RLS) is highly frequent among uremic patients; however, little is known about RLS risk factors in these patients. We evaluated the frequency of RLS and associated risk factors in Iranian patients on maintenance hemodialysis (HD) and peritoneal dialysis (PD).

The Validity and Reliability of the Persian Version of Kidney Disease Quality of Life Questionnaire-Short Form (KDQOL-SF) in Iranian Patients

Background: Health-related quality of life (HQOL) is greatly impaired in patients with end stage renal disease (ESRD). According to the importance of assessing HQOL in chronic disorders and the need for appropriate and specific instruments in this regard, this study aimed to evaluate the validity and reliability of the Persian version of the kidney disease quality of life questionnaire-short form (KDQOL-SF).

2011

Comparison of the effect of midodrine versus octreotide on hemodynamic status in cirrhotic patients with ascites

Background: In cirrhotic patients peripheral vasodilatation may decrease renal blood flow and subsequently raises plasma renin activity. Octreotide with several mechanisms causes peripheral arterial vasoconstriction. Midodrine is an alpha agonist and acts as a peripheral vasoconstrictor; therefore it may reduce plasma renin activity and improve renal function. In this study the effects of these two agents were compared on cirrhotic patients to determine their ability to reduce plasma renin activity and increase GFR.

Efficacy of Simethicone in Preparation Prior to Upper Gastrointestinal Endoscopy

Background: The presence of foam/bubbles in stomach and duodenum is a common problem during esophagogastroduodenoscopy (EGD) that interferes with precise evaluation of the mucosa. We evaluated the effectiveness of simethicone in reducing foam/bubbles in stomach and duodenum, endoscopy duration, and patient satisfaction.

Simethicone for the Preparation before Esophagogastroduodenoscopy

Background: The presence of air bubbles and foamin stomach and duodenumis a common problem during esophagogastroduodenoscopy (EGD).

Cost-Effectiveness Analysis of Colorectal Cancer Screening Methods in Iran

Background: Screening can prevent colorectal cancer from becoming advanced by early detection of precancerous lesions. Cost-effectiveness analysis of colorectal cancer screening methods is highly necessary due to increased prevalence, decreased age at onset and the limited budget in Iran.

Linguistic Validation of the Irritable Bowel Syndrome-Quality of Life Questionnaire for Iranian Patients

Background: There is a growing interest of clinical and epidemiological researches in the field of functional gastrointestinal disorders in our society. Accordingly, validated and culturally adapted instruments are required for appropriate measurement of variables specially the quality of life. The aim of our study was the linguistic validation of the Irritable Bowel Syndrome-Quality of Life questionnaire (IBS-QOL) for Iranian IBS patients with Persian language

Comparing the efficacy of biofeedback and balloon-assisted training in the treatment of dyssynergic defecation

Background: Dyssynergic defecation does not respond appropriately to routine treatments for constipation. Recently, research has shown that biofeedback therapy is useful in anorectal dyssynergia. To compare two treatment modalities for patients experiencing dyssynergic defecation.

Abnormal Liver Enzymes in Coal Tar Refinery Workers of Isfahan

Background: The effects of occupational exposure on liver function in oil refinery workers are not well known. In this study we evaluated the liver enzyme abnormalities among coal tar refinery workers.

Flutamide-induced Hepatotoxicity: A Case Report

Background: Flutamide is a non-steroidal antiandrogen commonly used in the treatment of prostate cancer. Severe hepatotoxicity occurs in few patients, yet may be fatal. To date, none of the reported cases of flutamide hepatotoxicity has demonstrated thrombocytopenia and chronic liver disease. We report the case of a 55-year-old male with prostatic adenocarcinoma who developed liver failure after six months of flutamide therapy.

High dose Senna or Poly Ethylene Glycol (PEG) for elective colonoscopy preparation: a prospective randomized investigator-blinded clinical trial

Background: The aim of this study was to determine the efficacy of two methods of colon preparation for colon cleansing in a randomized controlled trial.

Linguistic Validation of the Inflammatory Bowel Disease Questionnaire-Short Form (IBDQ-9) in Iranian Population

Background: Quality of life is significantly reduced in patients with inflammatory bowel disease (IBD). As there was no specific instrument for assessment of quality of life of Iranian IBD patients, we aimed to linguistically validate the Inflammatory Bowel Disease Questionnaire-Short Form (IBDQ-9) in Iranian IBD patients.

Effects of Carnitine Supplement on Dyslipidemia and Anemia in Hemodialysis Patients

Background: Carnitine deficiency is a common condition in patients on maintenance hemodialysis that contributes to dyslipidemia, anemia, and poor general health in these patients. We evaluated the effect of oral L-carnitine supplementation on lipid profile, anemia, and quality of life in hemodialysis patients.

Sirolimus-Based Immunosuppression for Treatment of Cutaneous Warts in Kidney Transplant Recipients

Background: Dermatological complications, especially skin infections, are very common following organ transplantation, and result in a lot of distress in the recipient. Herpes zoster, herpes simplex, and human papillomavirus infections are common infections in kidney transplant recipients, and therapeutic management is usually disappointing in immunosuppression state. We report here 2 cases of kidney transplant recipients who developed diffuse human papillomavirus-induced cutaneous warts with no response to conventional treatments.

The effects of hypotension on differences between the results of simultaneous venous and arterial blood gas analysis

Background: Analysis of venous blood gas (VBG) can represent arterial blood gas (ABG) analysis in patients with various diseases. The effects of hypotension on differences between the results of simultaneous venous and arterial blood gas analyses were reviewed.

Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus

Background: Evidence has shown a relationship between vitamin D deficiency and systemic lupus erythematosus (SLE). We evaluated the frequency of vitamin D deficiency and its association with disease activity in new cases of SLE.

Association between Major Dietary Patterns and Risk of Colon Cancer

Background: No information is available indicating the association between major dietary patterns and risk of colon cancer in Iran. This study was performed to assess the relationship between major dietary patterns and risk of colon cancer in Isfahan, Iran.

2010

The Effectiveness of Coping Strategies Training on Symptom Severity, Quality of Life and Psychological Symptoms among Patients with Irritable Bowel Syndrome

Background: Various psychological interventions were considered as part of the treatments of irritable bowel syndrome. However, the effectiveness of coping strategies in improving symptoms of this disease remains unclear. The objective of this study was to assess the effects of coping strategies training in treatment of irritable bowel syndrome (IBS).

Comparing Biofeedback Therapy and Balloon Defecation Training in Treatment of Dyssynergic Defecation

Background: Dyssynergic defecation does not respond appropriately to routine treatments of constipation. Recently, researches have shown that biofeedback therapy is useful in anorectal dyssynergia. This study compared two treatment modalities for these patients.

Metabolic syndrome in menopausal transition: Isfahan Healthy Heart Program, a population based study

Background: There is a remarkable increase in cardiovascular disease after menopause. On the other hand, metabolic syndrome as a collection of risk factors has a known effect on cardiovascular diseases. Hormone changes are considered as one of the main relevant factor regarding cardiovascular disease as well as some recognized relationship with metabolic syndrome’s components. This study was carried out in order to search for prevalence of metabolic syndrome during menopausal transition.

2009

New interpretation for diagnostic yield of ileoscopy: a prospective study and a brief review

Background: Lower digestive endoscopy is mostly limited to the cecum without any attempt to penetrate the ileum. One of the probable reasons is the expectation of a low diagnostic yield. This study aimed to examine the feasibility of ileoscopy during colonoscopy and its diagnostic yield

Which End Point Is More Comprehensive in Refl ecting Changes in Irritable Bowel Syndrome Treatment Trials?

Sonographic fatty liver in overweight and obese children, a cross sectional study in Isfahan

Background: Children’s obesity is a known health problem in the world and is a strong predictor of obesity in adulthood which increases the incidence of related diseases such as metabolic syndrome. According to the MONIKA project by the World Health Organization (WHO), Iran is one of the seven countries with a high rate of child obesity. Fatty liver is an abnormality related to metabolic syndrome, with higher prevalence in obese children according to some previous studies. This study investigates the presence of Sonographic Fatty Liver (SFL) in Iranian obese children in comparison with normal and overweight children.

Hypnotherapy as an Adjuvant for the Management of Inflammatory Bowel Disease: A Case Report

Background: Idiopathic inflammatory bowel diseases (IBDs) significantly affect the quality of life of sufferers. Improved quality of life and patient symptom management may be achieved through integrating psychological/behavioral interventions with pharmacologic treatments.

Effects of Weight Loss on Liver Enzyme Abnormalities Among Oil Refinery Workers

2008

Endoscopic polypectomy resection of blue rubber bleb nevus lesions in small bowel

Background: Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder characterized by cutaneous and gastrointestinal (GI) venous malformations. The treatment of BRBNS is primarily supportive and ablative. Ablative therapy involves endoscopic or surgical treatment of GI venous malformations. We describe a 20-year-old woman who had multiple venous malformations all over the GI tract as well as cutaneous lesions.

Primary chest wall lymphoma with no history of tuberculous pyothorax: Diagnosis and treatment

Objective: Primary chest wall neoplasm represents only 5% of chest wall neoplasm and among them primary chest wall lymphoma is uncommon.

Diagnostic Accuracy of IgA anti-Tissue Transglutaminase in Patients Suspected of Having Coeliac Disease in Iran

Background: As there are little data about the sensitivity of the IgA anti-tissue transglutaminase (IgA anti-tTG) antibody test in the clinical practice setting, we evaluated the sensitivity of this serologic test in a group of patients who were suspected of having coeliac disease and had serologic testing performed at commercial laboratories.

Do endoscopic markers still play a role in diagnosis of celiac disease?

Background: The primary aim of the study was “to determine the diagnostic value of endoscopic markers and fi nd ways to apply them in the diagnosis of CD”.

How Frequent is Celiac Disease among Epileptic Patients?

Background: A variety of neurological disorders have been reported in association with celiac disease (CD) including epilepsy, ataxia, neuropathy and multifocal leucoencephalopathy. The purpose of this study was to assess the prevalence of CD among epileptic patients.

Is microscopic colitis a missed diagnosis in diarrhea-predominant Irritable Bowel Syndrome?

Background: There are controversies about the importance of biopsies of normal colon mucosa in the investigation of patients with diarrhea predominant irritable bowel syndrome (IBS). On the other hand, microscopic colitis may be missed based on normal colonoscopy and laboratory examination in this group of patients

Chronic anal fissure: new approaches to chemical sphincterotomy

Ramadan fasting and inflammatory bowel disease

Background: Ramadan fasting may induce changes in gastrointestinal physiology. The effect of this fasting on inflammatory bowel disease (IBD) is not known. We conducted a cohort study in the month of Ramadan in 2006 to assess the effect of Ramadan fasting on IBD.

Pneumatic Balloon Dilation Therapy Is as Effective Esophagomyotomy for Achalasia

Background: For many years different treatments have been used for achalasia. However, esophagomyotomy (ESM) and pneumatic balloon dilation (PBD) have been considered the treatments of choice. Despite new research, some controversies still exist.

Safety and Efficacy of New Glyceryl Trinitrate Suppository Formula: First Double Blind Placebo Controlled Clinical Trial

Background: This study was designed to assess the safety and efficacy of 0.2 percent glyceryl trinitrate suppository form in the healing of chronic anal fissure.

How to put hypnosis into a placebo pill?

Background: Many case studies and several controlled clinical trials have indicated the effectiveness of hypnotherapy for some medical conditions. However, because of methodological inadequacies hypnotherapy is still criticized for not having strong scientific evidence to support its claims. While randomized placebo-controlled clinical trial is generally accepted as the gold standard study design, creating a credible placebo control for hypnotherapy is a major challenge. This paper recommends ‘‘neutral hypnosis’’ as a credible placebo control for hypnotherapy trials.

2007

Colonoscopic diagnosis of appendiceal intussusception in a patient with intermittent abdominal pain: A case report

Background: Intussusception of the appendix is a rare condition. Most cases are diagnosed during operation of the patients suspected to have appendicitis. In this report we present a seventy one year-old man with a history of periumbilical intermittent abdominal pain for several months.

A 40 years old woman with monolobar Caroli’s syndrome treated by left hepatic lobectomy

Background: Caroli’s disease (CD) is a rare congenital abnormality characterized by dilatation of intra hepatic bile ducts, which causes stone formation, recurrent cholangitis and higher risk for biliary malignancy. Association of this anomaly with congenital hepatic fibrosis is named Caroli’s syndrome (CS). The monolobar involvement of CS is a very rare condition, curable by partial hepatectomy. We report a 40 year-old woman with recurrent epigastric pain without icterus with normal AST, ALT and alkaline phosphates for 5 years due to left lobe Caroli syndrome which was diagnosed by CT scan and MRCP.

Achalasia and thyroid disease

Background: To investigate some possible etiologies of achalasia by screening patients with achalasia for some autoimmune diseases such as thyroid disease.

Are endoscopic findings predictive for the presence of H. pylori infection? What about indirect histologic findings?

Background: It is still controversial whether certain endoscopic features can be used to diagnose Helicobacter pylori related gastritis. Our aim was to determine how macroscopic findings were related to histomorphological changes and the presence of H. pylori in patients undergoing endoscopy.

2006

Where Does Hypnotherapy Stand in the Management of Irritable Bowel Syndrome? A Systematic Review

Background: Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause. Despite its prevalence, there remains a significant lack of efficient medical treatment for IBS to date. However, according to some previous research studies, hypnosis has been shown to be effective in the treatment of IBS. To determine the definite efficacy of hypnosis in the treatment of irritable bowel syndrome.

Airway resistance in irritable bowel syndrome as measured by impulse oscillometry

Background: Irritable bowel syndrome (IBS) is associated with bronchial asthma. However, published data on airway resistance or impedance in patients with IBS but without any respiratory symptoms are lacking.

Effects of Ramadan fasting on acute upper gastrointestinal bleeding due to peptic ulcer

Background: As, acid negatively affects duodenal and gastric mucosal defense, we designed this study to investigate if fasting during Ramadan can promote peptic ulcer and its complication, acute upper gastrointestinal bleeding.

Does delayed gastric emptying shorten the H pylori eradication period? A double blind clinical trial

Background: To evaluate the gastric emptying inhibitory effects of sugar and levodopa on H pylori eradication period.

Therapeutic approach to "downhill" esophageal varices bleeding due to superior vena cava syndrome in Behcet's disease: A case report

Background: One of the rare presentations of superior vena cava syndrome is bleeding of "downhill" esophageal varices (DEV) and different approaches have been used to control it. This is a case report whose DEV was eradicated by band ligation for the first time.

2005

Epidemiology of Colorectal Cancer in Isfahan Epidemiology of Colorectal Cancer in Isfahan Province

Background: The aim of this study was to assess epidemiology of colorectal cancer (CRC) in Isfahan, Iran.

Research Projects

Complete

Combination of diclofenac and aggressive hydration for the prevention of post-ERCP pancreatitis

PI: Mehri Hajalikhani, MD
Colleagues: Mahsa Khodadoustan, Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

http://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/1424

Prevalence of osteopenia and osteoporosis and related risk factors in patients with inflammatory bowel disease

PI: Ghazale Taheri
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

Investigation on the presence of mutation in exon 1,2,3 of interleukin 10 receptor A gene in patients with inflammatory bowel syndrome who suspected to primary immunodeficiency diseases

PI: Sahar Esfandyrai
colleagues: Roya Sherkat,MD, Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Scinces

Prevalence of Metabolic Syndrome in Inflammatory Bowel Disease Patients in Isfahan City in 2015 and 2016

PI: Emadaldin Habibi
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

Evaluation of health related quality of life (HRQOL) and important factors influencing HRQOL in patients with inflammatory bowel disease, in Esfahan in 2014 and 2015

PI: Farzane Habibi
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

Evaluation of reliability and validity of quality of life questionnaire of patients with inflammatory bowel disease

PI: Hamid Tavakoli, MD
Colleagues: Mohammad Hassan Emami, MD. Khoram, MD. Adilipour, MD. Zolfaghari, MD. Gholarmrezai, MD

Evaluation the efficacy of Glyceryl trinitrate (GTN) suppository form on the treatment of chronic anal fissure

PI: Mohammad Hassan Emami, MD
Colleagues: Abolfazl Aslani,MD. Samar Seyed Yahossein,MD

Mycophenolate mefetil is better than purine in the management of inflammatory bowel disease, survey on patients who are intolerant to purine

PI: Marzye Hashemi
Colleagues: Seyed Mohammad Hassan Emami, MD

Comparative study of the relative frequency of ulcerative colitis in patients with MS and normal population

PI: Shirin Ashkbousi
Colleagues: Seyed Mohammad Hassan Emami, MD

Study of variance analysis of repeated measures and its application in GNT suppository evaluation in treatment of chronic anal fissure

PI: Khadije Shahsavari
Colleagues: Seyed Mohamad Hassan Emami, MD

Preparation and evaluation of physiochemical properties of glyceryl trinitrate suppository for treatment of anal fissure

PI: Firooze Asadi
Colleagues: Mohamad Hassan Emami, MD

Inflammatory Bowel Disease Registry and Surveillance; Feasibility Study and Application

PI: Abdolmehdi Baghaei,MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funed by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

The role of mycophenolate mofetil in management of inflammatory bowel diseases

PI: Somaye Rasouli, MD
Colleagues: Seyed Mohammad Hassan Emami, MD

The structural pattern of the relationship between the Severity of symptoms, Illness perception and Resilience with Health-related quality of life in IBS patient

PI: Ghazale Teymouri
Colleagues: Elnaz Sajadyan, MD
Funded by: Islamic Azad University Isfahan (Khorasgan) Branch Research Center

Comparison of the effects of Aripiprazole with Nortriptyline on Irritable bowel syndrome

PI: Hojatolah Rahimi, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center

The effect of fasting on symptoms of reflux disease in 2015 and 2016 in Isfahan

PI: Hojatolah Rahimi, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center

Relationship between stress-coping strategies with severity of gastrointestinal symptoms, psychological factors and quality of life in patients with irritable bowel syndrome

PI: Mehrdad Zeynalian, MD
Colleagues: Seyed Mohammad Hassan Emami, MD

Sleep hygiene knowledge and practice in association with sleep quality in patients with irritable bowel syndrome

PI: Leyla Mirbagher
Colleagues: Seyed Mohammad Hassan Emami, MD

Evaluting the effect of Simethicone on decreasing foam and bubbles during upper gastrointestinal endoscopy

PI: Farnaz Torkzade
Colleagues: Seyed Mohammad Hassan Emami, MD

Evaluation of effectiveness of Fluoxetine on symptom and Quality of Life in Patients with Irritable Bowel Syndrome

PI: Forough Ghasedi. Ali Gholamrezai
Colleagues: Seyed Mohammad Hassan Emami, MD. Khoram, MD. Adilipour,MD. Tavakoli,MD

Evaluation of effectiveness of citalopram on symptoms and quality of life of patients with irritable bowel syndrome

PI: Hamid Tavakoli, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Khoram, MD. Adilipour,MD. Gholamrezai, MD

Evaluation of the Prevalence of Gastrointestinal Disorders in Isfahan

PI: Falah, MD. Abutalaian, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Khoram, MD. Adilipour,MD. Tavakoli,MD. Kabiri, MD. Talaei, MD.Farajzadegan, MD. Adibi, MD. Gholamrezai, MD

Evaluation of effectiveness of Yoga on Symptom and Quality of Life in Patients with Irritable Bowel Syndrome

PI: Atati, MD
Colleagues:Mohammad Hassan Emami, MD. Khoram, MD. Adilipour,MD. Tavakoli,MD. Gholamrezai, MD

Evaluation of effectiveness of hypnotherapy on the symptoms and quality of life of patients with irritable bowel syndrome

PI: Gholamrezai, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Khoram, MD. Adilipour,MD. Tavakoli,MD

Evaluation of effectiveness of recovery expectation and belief in cure in response to psychological treatment of irritable bowel syndrome

PI: Gholamrezai, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Nemati, MD. Daghaghzade, MD

Predicting the prognosis of Balloon Dilation therapy in Achalasia patients, Using a Novel Visual Scale

PI: Mehran Haghighi
Colleagues: Seyed Mohammad Hassan Emami, MD

Determination of Pulmonary Airway Resistance in Patients with Irritable Bowel Syndrome (Al-Zahra Hospital, Bamdad clinic 2004-2005)

PI: Behzad Dourshi
Colleagues: Babak Amra, MD

Study of the validation of irritable bowel syndrome quality of life questionnaire (IBS-QOL) for Iranian patients

PI: Ali Afshari
Colleagues: Seyed Mohammad Hassan Emami, MD

Determination of prevalence of causes of GIB and its treatment in patients hospitalized in Al- Zahra hospital of Isfahan in 1998

PI: Ali Afshari
Colleagues: Seyed Mohammad Hassan Emami, MD

Reflux and its effect on the severity of respiratory diseases- 2005- Chemical War Veterans of Isfahan 2006

PI: Bijan Ebrahimi, MD
Colleagues: Seyed Mohammad Hassan Emami, MD

The effect of fasting on dyspepsia symptom in 2015 and 2016 in Isfahan

PI: Hojatollah Rahimi, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center

Evaluation of effectiveness of Fluvoxamine on Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome

PI: Agah, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Gholamrezai,MD

Evaluation of Claudin4 expression rate in triple negative breast cancers with immunohistochemistry method and its relationship with some breast cancer prognostic factors

PI: Nadere Zareh,MD
Colleagues: Azar Naimi, MD, Elham Amjadi, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

Evaluation of Androgen receptor expression rate in triple negative breast cancers with immunohistochemistry method and its relationship

PI: Maryam Soltan, MD
Colleagues: Azar Naimi, MD, Elham Amjadi,MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

To study the sensitivity and specificity of BAT34CE and BAT26 mononucleotide markers microsatellite instability testing in tumor DNA of the patients at risk for Lynch Synsrome in comparison to the standard Promega kit in Isfahan

PI: Zeynab Abdollahi
Colleagues: Mehrdad Zeynalian, MD, Elham Amjadi, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Scinces

Evaluation and identification of potential MSI and MSS short-tandem repeat identifier markers and optimization of the diagnosis of heredity non-polyposis colorectal cancer syndromes

PI: Mehnaz Norouzi
Colleagues: Mohammad Shafii,MD, Elham Amjadi, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

Evaluation of sensitivity and specificity of BAT40 and BAT25 mononucleotide markers to detect microsatellite instability in colorectal tumors of HNPCC patients in comparison to promega standard kit

PI: Paniz Miyar
Colleagues: Mehrdad Zeynalian, MD, Elham Amjadi, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Scinces

Spatial variability of heavy metals in soil map units and their relationship with accumulation in plant and animal tissue and incidence of gastrointestinal cancer in Lenjanat region, Isfahan

PI: Reza Mohajer
Colleagues: Mohammad Hassan Salehi, MD. Seyed Mohammad Hassan Emami, MD

Cost analysis of colorectal cancer treatment in Isfahan province, July 2012

PI: Saied Masah
Colleagues: Seyed Mohammad Hassan Emami, MD

Cost effectiveness analysis of selected colorectal cancer screening methods in Iran

PI: Zahra Alame
Colleagues: Seyed Mohammad Hassan Emami, MD

The Epidemiology of Nonhereditary Colorectal Cancer in Isfahan province

PI: Ali Mohammad Fatemi
Colleagues: Seyed Mohammad Hassan Emami MD

Direct medical costs of colorectal cancer in Isfahan

PI: Majid Dvari, MD
Colleagues: Saied Masah. Seyed Mohamad Hassan Emami, MD

The evaluation of hMLH1, hMSH2 and hMSH6 genes mutation in HNPCC patient in Isfahan

PI: Mansour Salehi. Shahnaz amani
Colleagues: Seyed Mohamad Hassan Emami, MD. Amin Nemati

Evaluating diagnostic value of barium enema in colorectal tumor and non-tumor lesion

PI: Seyed Mohammad Hassan Emami, MD. Amin Nemati, MD
Colleagues: Ali Gholamrezai, MD. Mohammadreza Marasi

Evaluation of microsatellite instability in hereditary non polyposis colorectal cancer (HNPCC) patients

PI: Mansour Salehi, MD
Colleagues: Vida Homayouni, MD. Mehdi Nikbakht,MD

To detect the families who have hereditary polyposis colorectal cancer (non HNPCC hereditary colorectal cancer) in Isfahan and its influence on future management of individuals who are at risk for them

PI: Seyed Mohamad Hassan Emami, MD
Colleagues: Seyed Mohamad Ali Fatemi, MD. Ziba Farajzadegan, MD

Investigation of relationship between dietary habits & colorectal cancer risk in Isfahan population - 2004-2005

PI: Seyed Mohamad Hassan Emami, MD
Colleagues: Maryam Adeli. Nahid Abdar. Leyla Loghmanian. Akram Pourshams. Ziba Farajzadegan

Quality Of Life in Patients With Colorectal Cancer In Isfahan 2006

PI: Seyed Mohamad Hassan Emami, MD
Colleagues: Fatane Gholami, MDZiba Farajzadegan, MD

Relation between physical activity and colorectal cancer

PI: Reyhane Rasouli
Colleagues: Seyed Mohammad Hassan Emami, MD. Parasto Golshiri

Evaluation of Geographical Distribution of Colorectal Cancer in Isfahan during 7 years (1996-2003)

PI: Seyed Mohammad Hassan Emami, MD
Colleagues: Ladan Salamatyan, MD. Maryam Bahreynyan, MD

To evaluate the relation between stage and histological differentiation and the 3 and 5-year disease free survival of patients with colon cancer undergone surgery alone in comparison to those who have received adjuvant chemotherapy

PI: Mohammad Hassan Emami, MD
Colleagues: Hamid Emami, MD. Farzane Ashrafi, MD. Farborz Mokarian, MD

Evaluation of three SNP frequency in the genomic DNA samples of colon cancer patients and their correlation with the disease in visited patients in poursina hakim research center of Isfahan

PI: Abdolreza Dara
Colleagues: Rasoul Salehi, MD.Seyed Mohammad Hassan Emami, MD . Faeze Mohamad Hashem. Vahid Bahram Beygi. Yaser Mansouri

Nucleostemin expression in CD133 + and CD133 cells in patients with colon cancer

PI: Seyed Mohammad Hassan Emami, MD
Colleagues: Abas Rezai,MD. Marjan Ghare Guzlu,MD. Mansour Salehi,MD. Seyed Mohsen Hoseyni. Hamidrez Mirzayi. Seyed Mohammad Mehdi Mirmohseni. Mohammadreza Piri Ardekani. Ziba Farajzadegan

Survivin expression in CD133 + and CD133 cells in patients with colorectal cancer

PI: Seyed Mohammad Hassan Emami,MD
Colleagues: Abas Rezai,MD. Marjan Ghare Guzlu,MD. Mansour Salehi,MD. Seyed Mohsen Hoseyni. Hamidrez Mirzayi. Seyed Mohammad Mehdi Mirhoseyni. Mohammadreza Piri Ardekani. Ziba Farajzadegan

Evaluation of diagnostic value of alarm symptoms, dyspepsia and endoscopy in compared with Biopsy

PI: Masoud Ataei, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

Evaluation of some microRNA (hsa-mir-510-3p, hsa-mir-548av-5p, hsa-mir-30c-1-3p, hsa-mir-300) expression related to colorectal cancer in normal and tumor tissue samples

PI: Ali Ghorvi niya
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

Assessment of the celiac prevalence in cerebellar ataxic patients in Isfahan city

PI: Sepideh Alahdadian
Colleagues: Mohammad Reza Najafi, MD, Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

Frequency of Celiac Disease among Epilepsy in Isfahan

PI: Seyed Mohamad Hassan Emami, MD
Colleagues: Hajar Taheri, MD. Soheyla Kouhestani, MD. Masoud Etemadifar. Ahmad Chitsaz. Saaid Karimi. Marzye Hashemi

Evaluation the association of HLA-DQb alleles with celiac disease in Iranian population

PI: Mehdi Zamani, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Seyed Mehran Modares Sadeghi. Vajihe Ostadi. Soheyla Kouhestani, MD

Frequency of Celiac Disease in Suspicious Children and Adolescents In Isfahan

PI: Seyed Mohammad Hassan Emami,MD

Colleagues: Soheyla Kouhestani, MD. Somaye Karimi, MD

Comparison of the quantity, phenotype and activity mode of epithelial and lamina propria lymphocytes in duodenum of celiac patients and control group in Isfahan

PI: Mohsen Masjedi, MD
Colleagues: Hadi Nataj. Seyed Mohammad Hassan Emami, MD. Fereshteh Saheb Fosoul

Frequency of Celiac Disease among Patients with Irritable Bowel Syndrome

PI: Seyed Mohammad Hassan Emami, MD
Colleagues: Soheyla Kouhestani, MD. Ali Gholamrezai, MD. Mahzouni, MD. Hamed Daghaghzade, MD

Frequency of Unrecognized Celiac Disease among Patients with Chronic liver Disease in Iran

PI: Seyed Mohammad Hassan Emami, MD
Colleagues: Soheyla Kouhestani,MD. Marziye Hashemi, MD. Peyman Adibi,MD. Tavakoli, MD

Frequency of Celiac Disease in Suspicious Adult Patients in Isfahan

PI: Mohammad Hassan Emami, MD
Colleagues: Soheyla Kouhestani, MD. Somaye Karimi, MD. Hamid Tavakoli, MD. Hamed Daghaghzade, MD. Amin Nemti, MD

Determine of relative frequency of celiac disease in anemic patients of unknown etiology or patients with iron deficiency anemia with recurrent or refractory to iron therapy in Isfahan

PI: Seyed Mohammad Hassan Emami, MD
Colleagues: Soheyla Kouhestani,MD. Amin Nemati, MD. Najme Tavakol. Fariboez Mokaryan, MD. Somaye Karimi, MD

Studying sensitivity and specificity of IgA anti-tissue transglutaminase (tTG) antibody in patients suspicious of celiac disease in Isfahan

PI: Seyed Mohammad Hassan Emami, MD
Colleagues: Somaye Karimi, MD. Soheyla Kouhestani, MD. Marzye Hashemi. Hajar Taheri

The effect of self care program on the quality of children’s life with Celiac disease at Isfahan celiac Association in 2016-2017

PI: Zahra Ezadi
Colleagues: Shore Zyaei, Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

The evaluation Marsh classification, gene expression and serum level of midkine and C-reactive protein in the patients with celiac disease and healthy individuals in Isfahan city

PI: Shima Soltani
Colleagues: Mohsen Masjedi, MD, Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

How Frequent is Celiac Disease among Epileptic patients?

PI: Hajar Taheri
Colleagues: Mohammad Hassan Emami, MD

Should We look for Celiac Disease Among all Patients with Liver Test Abnormality?

PI: Marzye Hashemi
Colleagues: Seyed Mohammad Hassan Emami, MD

Effect of Ramadan fasting on alanine transferase (ALT) in nonalcoholic fatty liver disease (NAFLD)

PI: Hojatollah Rahimi, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center

Prevalence and types of anemia in IBD patients in Isfahan between 2015 and 2016

PI: Ali Ghorvi niya, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Isfahan University of Medical Scinces

Breast Cancer Detection by Sample Image Processing through Deep Learning

PI: Somayye Jafarali Jasbi, PhD
Colleagues: Elham Amjadi , MD

Prevalence of colorectal polyps in average risk and high risk patients undergoing colonoscopy in Isfahan from 2007 to 2018

PI: Mohammad Hassan Emami. MD

Colleagues: Fatemeh Maghool. Ph.D, Elham Amjadi. MD,Hengameh Valian, Medical Stundent Aida Heidari B.S. Anasik Lalazaryan MS.

The prevalence of screening colonoscopy among first-degree relatives of patients with colorectal cancer and relating factors in Isfahan, between 2018-19

PI: Zahra Rastin Maram, Medical student
Colleagues: Mohammad Hassan Emami, MD. Fatemeh Maghool , Ph.D

Clinical and Genetic Assessment of Hereditary Colorectal Cancer Syndromes (Lynch Syndrome, Familial Adenomatous Polyposis, and MUTYH-associated Polyposis Syndrome) in Iran: A Cross-sectional Multicenter Study

PI: Ladan Goshayeshi, MD
Colleagues: Mohammad Hassan Emami, MD. Fatemeh Maghool, Ph.D

Evaluation of zinc concentration in serum of patients with Crohn's disease in Isfahan and comparison with control group

PI: Zahra Soltani, Medical Student
Colleagues: Rahmat allah Rafiei, MD. Abdolmehdi Baghaei, MD

Study the prevalence of depression in patients with Celiac disease in Isfahan, 2019

PI: Zahra Ahmadi, Pharmacology Student
Colleagues: Atefe Vaezi, MD. Bahar Sadeghi, Forough Nasr Esfahani, Fateme Sadat Mostafavi, Negar Maleki, Nahid Jamali, PHD. Mohammad Hassan Emami, MD

Comparison of Candida colonization in the esophagus and stomach of patients taking proton pump inhibitors drugs with histamine receptor antagonist in Isfahan during 2019-2020

PI: Batoul Motaghi

Colleagues: Rasoul Mohammadi. Ph.D, Mohamad Hassan Emami. MD

Frequency comparison and Evaluation of phenotypic and genotypic characteristics of Adherent Invasive Escherichia coli isolated from patients with colorectal cancer in Isfahan

PI: Razye Kamali. Ph.D
Colleagues: Hosein Fazeli. Ph.D, Mohamad Hassan Emami. MD, Vajihe Karbasi zadeh. Ph.D, Fateme Maghool Ph.D.

The Comparison of the Effectiveness of Transdiagnostic Treatment and the Acceptance and Commitment Therapy (ACT) on Emotion Regulation, Illness Perception, Helth Locus of Control, and the Quality of Life in Patients with Irritable Bowel Syndrome (IBS)

PI: Zahra Karimyan
Colleagues: Abbas Haghayegh. Ph.D, Mohamad Hassan Emami. MD. Mostafa Raisi, MD

comparison two method hydro colon therapy and PEG in colon preparation before colonoscopy

PI: masoud hasanvand, Medical student
Colleagues: Saeid Kheyri. MD, Mohammad Hassan Emami. MD, Rahmatolah Rafii. MD, Hojatollah Rahimi. MD, Alireza Fahim. MD

The Effect of 12 Weeks Combined Training with DASH Diet on ALT Enzyme Level, Fatty Liver and Anthropomorphic Index in Patients with Non-Alcoholic Fatty Liver Disease

PI: Shila hassanian fard, MS, Sport Physiology

Colleagues: Khosro Jalai. PhD, Mohammad Hassan Emami. MD, Hojatollah Rahimi. MD, Nazila Tayari. MD

Modeling structural relationships of life in inflammatory bowel patients with perceived stress perceived pain and concern

PI: Shima Mansourifar, MS,
Colleagues: Hassan Rezayi. MD, Mohammad Hassan Emami. MD

Evaluation of the relationship between consumption of lactose-containing foods and gastrointestinal symptoms in patients with inflammatory bowel diseases in comparison to healthy control group

PI: Pejman Alavinejad, MD
Colleagues: Mohammad Hassan Emami, MD. Fatemeh Maghool, PhD
Founded by: ahvaz jundishapur university of medical sciences

The effectiveness of short-term psychological training on the ability of mindfulness, anxiety sensitivity and symptoms of patients with irritable bowel syndrome

PI: Niloufar Nikgoftar, Medical Student
Colleagues: Fatemeh Zargar, MD

Comparison of efficiency and side effects of intrauterine insemination (IUI) catheters, mandrel contain and without mandrel, products of Slamtyar Hakim Engineering company, in infertile couples referred to Shahid Beheshti hospital in 2019

PI: Elham Naghshineh
Colleagues: Fatemeh Maghool. PhD, Hatav Ghasemi Tehrani. MD, Farahnaz Mardanyan. MD, Nasrin Bagheri. MD

Prevalence of celiac disease and its relationship with changes in EEG in patients with ataxic cerebellar type in Isfahan

PI: MS Allahdadian
Colleagues: Nahid Jamali. PhD, Mohammad Hassan Emami MD

Ongoing

Evaluation of genes involved in celiac disease in affected patients in Isfahan province using NGC (Next Generation Sequence) method

PI: Ghazale Fatemi, PhD
Colleagues: Mansour Salehi, MD, Seyed Mohammad Hassan Emami, MD
Funded by: Tehran Islamic Azad University Research Center

Role of Heavy Metals in Colorectal Cancer

PI: Mohammad Hassan Emami, MD
Colleagues:Fatemeh Maghool , Ph.D. Abdolmehdi Baghaei ,MD

Standardized Care Survey Among Iranian IBD Patients: Isfahan 2019

PI: Hanan Hoseini Acharshi, Medical Student
Colleagues: Abdolmehdi Baghaei, MD

Primary Sclerosing Cholangitis (PSC) Registry and Monitoring (Surveillance): Feasibility and Application (An Action Research)

PI: Tahere Taheri, Medical Student
Colleagues: Abdolmehdi Baghaei, MD

Describe the natural history of Primary sclerosing cholangitis (PSC) in Iranian popular

PI: Zahra Arefyan, Medical Student
Colleagues: Abdolmehdi Baghaei, MD

Design and implementation of colorectal cancer registration and monitoring system in Isfahan city

PI: Fatemeh Maghool, PhD
Colleagues: Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Cente

The Effectiveness of cognitive behavioral therapy on fear of cancer recurrence, cognitive function and pain catastrophizing in colorectal cancer patients

PI: Yeganeh Ebrahimi, MS
Colleagues: Hassan Rezaei, PhD. Fatemeh Maghool, PhD

Identification of new and important molecular pathways in the pathogenesis of colon cancer, with a novel biological system approach

PI: Mina Shahnazari, MS
Colleagues: Akram Jalali, PhD., Saeid Afshar, PhD., Masoud Saeidi Jam, PhD., Mohammad Hassan Emami, MD

The study of the frequency and correlation between HLADQB1*02 allele and two genetic variants associated with tissue transglutaminase protein reduced function in celiac patients

PI: Fahimeh Kamali, MS
Colleagues: Vahideh Hassanzade, PhD.,Mohammad Hassan Emami, MD

Pneumatic Balloon Dilatation for Achalasia Cardia : outcome , complications , success . an extended follow up

PI: Farnoush Ahmadyan, Medical Student

Colleagues: Mohammad Hassan Emami, MD

Structural model of psychosocial adaptation to illness based on perceived stress, health-promoting behaviors and mental coherence with self-compassion mediated in patients with irritable bowel syndrome

PI: Farzaneh Forouzanfar, PhD

Colleagues: Mojtabah Ansari Shahidi, Ph.D, Sheyda Jabalameli Ph.D, Mohammad Soltanizadeh Ph.D, Mohammad Hassan Emami, MD.

Comparison of the Effectiveness of Mindfulness-Based Stress Reduction and Intensive Short-Term Dynamic Psychotherapy on the Sense of Coherence, Emotional Processing, death anxiety and Body Image in Patients with Colon Cancer

PI: Andalib, Ph.D
Colleagues: Mohammad Hassan Emami, MD

Investigating the Situation of Some Heavy Metals and Asbestos in Soil and Atmospheric Dusts of Isfahan Region with an Implication for Human Health

PI: Shahrbanoo Jorkesh, Ph.D
Colleagues: Mohammad Hassan Salehi, PhD. Reza Mohajer, PhD, Mohammad Hassan emami,MD. Monire Khadem, PhD.

Comparative bioequivalence study (comparative pharmacodynamics) of Variopeptyl® 11.25 mg and Diphereline® 11.25 mg in Patients with non-metastatic prostate cancer Volunteers

PI: Pouria Adeli, MD
Colleagues: Fatemeh Maghool, PhD. Abolfazl Mostafavi, Ph.D

Evaluation of main metabolites of 1Carbone metabolism cycle and sperm function in individuals with celiac disease

PI: Marzye Tavalaei. MD, Seyed Mohammad Hassan Emami, MD
Colleagues: Mohammad Hossein Nasr Esfahani. MD, Fatemeh Maghool, PhD

The effect of an educational-supportive program based on chronic care model on self-efficacy and health related quality of life of patients with ulcerative colitis

PI: Zahra Sepehryan, MS
Colleagues: Sedighe Farzi. PhD, Mohammad Hassan Emami. MD, Mohammad Javad Tarahi. MD.

Study of Phenotype and genotype of patients with colon polyposis

PI: Ladan Goshayeshi, Md
Colleagues: Maryam Afraze, MD, Mohammad Reza Abbaszadegan. MD, Abbas Abdolahi. MD, Roshan Ravan. MD, Mohsen Ali Akbaryan. MD, Hooman Mosanen. MD, Lena Goshayeshi. MD, Ali Bahari. MD, Hassan Vosughi. MD, Kambiz Akhavan. MD, Mahla Rahmani. MD

Evaluation and comparison of diagnostic accuracy of endometrial biopsy with endometrial sampling catheter, a product of Hakim Health Engineering Company, and dilatation and curettage in patients referred to Shahid Beheshti Hospital in Isfahan in 2019

PI: Fariba Behnamfar, MD
Colleagues: Fatemeh Maghool. PhD, Safoura Rouholamin. MD, Fahimeh Sabet. MD, Parvin Rajabi. MD, Arezoo Bohrani. MS.

Detection of Colon Polyps Using Colonoscopy Images Processing

PI: Javad Mozafari,Ms
Colleagues: Shahryar Baradaran Shokouhi, PhD, Abdolah Amirkhani, PhD, Seyed Mohammad Hassan Emami, MD
Funded by: Iran University of Science and Technology (IUST)

Study The Expression of RPS19 and RPL29 genes and related CircularRNAs in Breast Cancer

PI: Ali Heidarpour, Ms
Colleagues: Hosein Teimouri MD, Mohammad Reza Saberyan, Mohammad Moazeni MD, Maryam Tabatabaeian MD, Elham Amjadi MD, Hadi Reisi PhD, Reza Mirfakhraei PhD
Funded by: Shahrekord University of Medical Sciences

Evaluation of the Relationship between Dietary Inﬂammatory Index with odds of Colorectal Cancer and Advanced Adenomatous Polyp in Patients Referred to Gastrointestinal Clinic in Isfahan Between 2019-2022

PI: Zahra Mousavi. Medical Student, Elahe Nyazi. Medical Student
Colleagues: Sayed Mohammad Hassan Emami MD, Fatemeh Maghool PhD, Samane Mohammadzade PhD, Parisa Rouhani Ms, Parvane Sanei PhD, Alireza Fahim MD, Anasik Lalazaryan Ms.
Funded by: Isfahan University of Medical Sciences

Systematic review and meta-analysis of the relationship between Mediterranean diet and the risk of advanced colon adenoma

PI: Sayed Mohammad Hassan Emami MD
Colleagues: Fatemeh Maghool PhD, Samane Mohammadzade PhD, Ziba Farajzadegan MD, Rahele Karimi PhD, Ali Ehsan Dehkordi MD
Funded by: Isfahan University of Medical Sciences

Investigation of heavy metals concentrations and trace elements in muscle, kidney and liver of livestock in Middle Eastern countries

PI: Sayed Mohammad Hassan Emami MD
Colleagues: Fatemeh Maghool PhD, Samane Mohammadzade PhD, Safoora Mohammadzade PhD, Faride Saberi PhD, Alireza Fahim MD, Ali Ehsan Dehkordi MD, Mohammad Abdolvand PhD
Funded by: Isfahan University of Medical Sciences

Evaluation of antibiotic resistance pattern and abundance of integrons in Adherent Invasive Escherichia coli isolated from patients with colorectal cancer or advanced adenoma polyps referred to Poursina Hakim Gastroenterology Clinic

PI: Aida Heydari, Ms
Colleagues: Razye Kamali PhD, Fatemeh Maghool PhD, Samane Mohammadzade PhD, Alireza Fahim MD, Tahere Safari PhD
Funded by: Isfahan University of Medical Sciences

Evaluation of the effectiveness of chemotherapy drugs on tumor organoids from patient tissue in breast cancer

PI: Amir Ali Hariri, Pharmacology student
Colleagues: Mina Miriyan PhD, Pourya Adeli MD, Maryam Tabatabaian MD, Fatemeh Maghool MD
Funded by: Isfahan University of Medical Sciences

Systematic review and meta-analysis of lead and cadmium concentrations in muscle, kidney and liver of livestock with the assessment of human health risk assessment in Iran

PI: Mohammad Hassan Emami, MD
Colleagues: Fatemeh Maghool.PhD,Seyed Mohammad Hassan Emami.MD,Atefe Amerizade.MD,Rahele Karimi.MD,Sayed Ali Ehsan Dehkordi.MD
Funded by: Isfahan University of Medical Scinces

Evaluation of safety of an indigenous Allogeneic Colon Cancer Cell Vaccine-immunotherapy combined with chemotherapy in stage 4 colorectal cancer patients

PI: Mohammad Hassan Emami, MD
Colleagues: Samaneh Mohammadzade PhD, Fatemeh Maghool PhD, Nafise Esmail PhD, Shaghayegh Haghjoo PhD, Pourya Adeli MD
Funded by: Poursina Hakim Digestive Diseases Research Center, Iran Biotech Fund

Investigating the relationship between tTG antibody level, marsh system classification and clinical manifestations in celiac patients

PI: Reza Gholamrezaei, Medical Student
Colleagues: Seyed Mohamad Hassan Emami MD, Atefe Vaezi MD
Funded by: Isfahan University of Medical Sciences

Targeted treatment of cancer using whole exome sequencing

PI: Sayed Amir Bahreini, MD
Colleagues: Sayed Shahryar Alavi Hejazi, Sayed Mohammad Hassan Emami MD, Elham Amjadi MD, Maryam Tabatabaian MD
Funded by: Isfahan University of Medical Scinces

Evaluation of PD-L1 expression and relation to some prognostic factors in primary triple negative breast cancer patients admitted to AL-ZAHRA hospital in year 2016-2021

PI: Arefe Ezadi, pathology resident
Colleagues: Maryam Soltan MD, Azar Naimi MD, Elham Amjadi MD
Funded by: Isfahan University of Medical Scinces

The association between type of chemotherapy and tumor infiltrating lymphocytes with patient survival in patients with triple negative breast cancer from 2016 to 2019

PI: Anahita Khosarvi, Medical Student
Colleagues: Ali Akhavan MD, Mitra Heidarpour MD, Elham Amjadi MD, Elham Moazam MD
Funded by: Isfahan University of Medial Scinces

Prevalence of colorectal polyps in average risk and high risk patients undergoing colonoscopy in Isfahan from 2008 to 2018

PI: Hengame Valian, Medical Student
Colleagues: Ali Akhavan MD, Mitra Heidarpour MD, Elham Amjadi MD, Elham Moazam MD
Funded by: Isfahan University of Medial Scinces

Assessment the prevalence of colonoscopic screening among first-degree relatives of patients with colorectal cancer and relating factors in Isfahan, between 2018-19

PI: Zahra Rastinmaram, Medical Student
Colleagues: Sayed Mohammd Hassan Emami MD, Fatemeh Maghool MD, Mohammad Reza Hakimiyan MD
Funded by: Isfahan University of Medial Scinces

Evaluation of safty of an indigenous Autologous Colon Cancer Cell Vaccine-immunotherapy combined with chemotherapy in stage 4 colorectal cancer patients

PI: Mohammad Hassan Emami, MD
Colleagues: Samane Mohammadzade PhD, Fatemeh Maghool PhD, Nafise Esmail PhD, Alireza Fahim MD, Mostafa Raisi MD, Amin Bahreini MD, Masoud Moghtaderi MD, Mehran Sharifi MD, Alireza Saadatmand MD, Hojatallah Rahimi MD, Pourya Adeli Md
Funded by: Isfahan University of Medical Sciences

Investigating the distribution of colonoscopy findings in patients with positive stool immunochemical test (FIT) referred to Poursina Hakim Gastrointestinal Diseases Clinic in Isfahan between 2011-2022

PI: Abbas Lalegani, Medical Student
Colleagues: Mohammad Hassan Emami, MD. Fatemeh Maghool. PhD. Elham Amjadi MD, Samaneh Mohammadzade PhD, Anasik Lalazaryan, MS

Investigating the relationship between primary breast tumor size and sentinel lymph node involvement in patients admitted to Seyed al-Shohad Hospital in Isfahan in 2017-2022

PI: Negar Panahi, Medical Student
Colleagues: Azar Naimi, MD, Elham Amjadi,MD

Investigation of frequency, survival and risk factors of primary sclerosing cholangitis in patients who admitted to Poursina-Hakim clinic in Isfahan between 2002-2023

PI: Reza Ebrahimi, Medical Student
Colleagues: Mohammad Hassan Emami, MD. Fatemeh Maghool PhD, Masoud Moghtaderi MD, Reza Solouki MD, Abdolmehdi Baghaei MD, Amirhosein Hekmat, Medical Student, Anasik Lalazaryan MS

Pharmacotherapy and drug interactions of outpatient elderly IBD patients and evaluation of direct medical costs

PI: Saba Rashidi, Medical Student
Colleagues: Amirhooshang Zargarzade MD, Mohammad Hassan Emami MD

Evaluation the level of methylation and expression of PD-1 and its ligand genes in the tissues of healthy people compared to Patients with Colorectal Cancer or Advanced Adenomatous Referred to Gastrointestinal Clinic in Isfahan Between 1398-1401

PI: Mohammad Hassan Emami, MD
Colleagues: Fatemeh Maghool PhD, Samaneh Mohammadzade Phd, Alireza Fahim MD, Elham Amjadi MD, Parisa Kadkhodaei MS

A histopathological image dataset of colorectal cancer grading in machine learning algorithm

PI: Elham amjadi MD
Colleagues: Hamidreza Bolhasani PhD

The combination effect of phage with Lactobacillus acidophilus and Lactobacillus plantarum on adherent–invasive Escherichia coli (AIEC) isolated from biopsy samples of colorectal cancer (CRC) patients in vitro

PI: Sharare Moghim, PhD
Colleagues: Bahram Nasr Esfahani, PhD. Mohammad Hassan Emami, MD. Arezoo Mirzayi, PhD. Forough Tavakoli, PhD. Alireza Fahim, MD. Fatemeh Mohammadi, PhD

Cross-disease gene co-expression analysis in patients with Pancreatic cancer and Chronic Pancreatitis

PI: Fariba Dehghanian, PhD
Colleagues: Sadegh Valian, MD. Mohammad Hassan Emami, MD. Fatemeh Maghool PhD, Fatemeh Nouri MS

About uS

Digestive Diseases Research Center (DDRC) is an affiliated research center to Poursina Hakim Institute, a private organization for health promotion, patient care, research and education in biomedical sciences in the field of gastrointestinal diseases. Research activities have begun since 2000, just at the same time that Poursina Hakim Institute initiated its activity leading to establishment of Poursina Hakim Research Center in 2008. The institute including the research center was finally approved by the Iranian Ministry of Health and Medical Education as DDRC in 2015. Our research team is comprised of researchers in different fields including medicine, pharmacy, microbiology, pathology, statistics, etc. with the goal to translate research from bench- to-bedside benefiting mankind.